Each of these comes straight from the panel with Justin Woods and AgentM from the Marvel Booth at SDCC.
-The following heroes are announced
-Spider-Girl (Anya Corazon)
-Spider-Girl (May Parker)
-Silk
-Spider-Gwen
-Spider Man 2099
-The next Worthy will likely be Nerkkod, Breaker of Oceans
-Spider-Ham is fairly low on the production list, 'somewhere below Howard the Duck and Slapstick'
-No alternate uniforms were directly announced, but more are on the way