After suffering three defeats in a row from the wall crawling, web-slinging superhero Spider-Man, Doctor Octopus realized he required assistance from others in order to defeat Spider-Man. He got in touch with every known super-villain Spider-Man had crossed paths with and only five responded: the airborne assassin the Vulture, the electrifying Electro, the wild Kraven the Hunter, the mysterious master of illusions Mysterio and the shape-shifting Sandman. Knowing he'd never be able to keep the team together for long, Doctor Octopus quickly formulated a battle plan that would give each of the villains personal glory and Spider-Man an early death. Each individual member of the Sinister Six would battle Spider-Man in a carefully chosen location, until the point where the wall-crawler was no more.
(Doctor Octopus) Former Leader
as Quentin Beck
Eddie Brock (Sandman's Sinister Six)
MacDonald Gargan (Sinister Twelve)
Sinister Six Effects
|Sinister Six||Former Members of the Sinister Six|
|Superior Foes||Current or former members of the Superior Foes of Spider-Man|