MAAInsiders revealed on Twitter that Scream will be one of the villains in Spec Ops 18.
Scream is the "daughter" of the Venom symbiote.
The name of Scream's host is Donna Diego.
Donna eventually became a hero in the comics, before she was killed by Eddie Brock.
The in-game Scream seems to be controlled by the Symbiote, as on several occasions it has referred to the human host as a "meat puppet".
Of the 5 symbiotes forcibly spawned from Venom by the Life Foundation, Scream is the only symbiote who did not merge to become the entity known as Hybrid.
In the comics, it's Scream who is responsible for killing the hosts of the Agony, Lasher, Riot, and Phage symbiotes which create the Hybrid symbiote. In the game, the Circle of 8 killed them (though her dialogue in Spec Ops 18 suggests she played a part in their deaths).
Scream killed her "brothers" and "sister" with a sonic knife in the comics, a similar weapon is the drop item in her SO 18 boss fight.
She was first referred to as Scream in the video game "Venom & Spider-Man: Seperation Anxiety" (an early Playdom game) and next in the Venom action figure line, in the comics she was referred to originally as simply Female Symbiote.