The Inheritors are a clan of totemic hunters who fed on the life force of Totems, beings that connect the animal and Human kingdoms, originaly from Earth-000. They have battled and fed on both totem avatars as well as totemic Gods. At one point, they sought to defeat the spider deity the Master Weaver. The clan mother and her offspring Bora, Verna, Brix, Daemos, Morlun, Jennix and Karn attacked him at his home. But when Karn got a chance to strike, the Weaver revealed Karn had no pleasure with death and wished he could create and not destroy. Karn hesitated and his mother attacked the Weaver and was killed. While Karn was in shock, his father, Solus, arrived and subjugated the Master Weaver with his siblings. Karn was confined to wear a mask to hide his shame and became an outcast. Seeing that the Weaver's power could be used, they used chains designed by Jennix to control the Master Weaver's power in order to travel between dimensions and hunt all Spider-Totems in the Multiverse.
When the Inheritors managed to gather three spider-totems needed to perform a ritual, The Other, The Scion, and The Bride, the Spider-Army formed to oppose the Inheritors travelled to their base, Loomworld, to stop them.