- MAAInsiders revealed on Twitter that Hybrid would be the group boss for Spec Ops 18.
- The hosts of Agony, Lasher, Riot, and Phage (the symbiotes that make Hybrid) have all been subsequently killed by the Circle of 8, thus paving the way for their merger into Hybrid. In the comics Scream was responsible for the deaths of the hosts.
- Hybrid's group boss variants have the color schemes of Riot (Bruiser), Agony (Infiltrator), Phage (Scrapper), Lasher (Tactician), and Hybrid's normal color (Blaster).
- Hybrid is the first Group Boss to be recruitable through Lockboxes.
- Hybrid is the first hero recruitable through lockboxes to have alternate costumes (unless one counts Loki, who's hero costume is different from his boss costume) and to have released more than two alternate uniforms at the same time.
- Hybrid's ability names (except Backstab) are based on symbiotes that integrate him.
- Hybrid currently has the highest amount of Character restricted E-iso's and A-iso's.