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Contents
  1. Chapter 6 - When Opportunity Knocks
    1. Mission 1 - Unknown Intel
    2. Mission 2 - Ancient Knight
    3. Mission 3 - Dark Complications
    4. Mission 4 - Harvester of Souls
    5. Mission 5 - Clash of Titans
    6. Premium Mission: Fourth Wall


Chapter 6 - When Opportunity Knocks[]

Mission 1 - Unknown Intel[]

Heroic Battle
Baron Zemo Icon Baron Zemo Tacticianicon
Passive:
Deadly Lunge - Counters attacks made by enemies marked with The Baron's MarkDeadly Lunge - Counters attacks made by enemies marked with The Baron's Mark
Caught Off-guard - Vulnerabile to StunCaught Off-guard - Vulnerabile to Stun
Baron Strucker Icon Baron Strucker Tacticianicon
Passive:
Teleport - Chance to teleport to Avoid incoming attacksTeleport - Chance to teleport to Avoid incoming attacks
Caught Off-guard - Vulnerabile to StunCaught Off-guard - Vulnerabile to Stun
Viper Icon Viper Infiltratoricon
Passive:
Death March - Viper and her lieutenants gain the ability to counter attacks; Chance to counter scales as health decreasesDeath March - Viper and her lieutenants gain the ability to counter attacks; Chance to counter scales as health decreases
Caught Off-guard - Vulnerabile to StunCaught Off-guard - Vulnerabile to Stun

Heroes Required: Captain America
Allies: Falcon
Appears in: Chapter 6 - When Opportunity Knocks: Mission 1 - Unknown Intel
Potential Gear Reward: Random Deploy Gear, Empowered Iso-8 003Leading Empowered Isotope-8, Empowered Iso-8 007Swooping Empowered Isotope-8
Total Hero Cost: 90 Command point icon

This battle features the legendary Cap-Falcon duo against three HYDRA leaders: Zemo, Strucker and Viper. As always, using an alternate outfit for Captain America will make the battle easier: the best one for this battle is the Scrapper Captain Steve Rogers alt. All three bosses have a unique passive debuff called
Caught Off-guard - Vulnerabile to StunCaught Off-guard - Vulnerabile to Stun
 Caught Off-guard, which will allow you to
Stun (1 turn) - Loses next turn; Reduced chance to dodgeStun (1 turn) - Loses next turn; Reduced chance to dodge
 Stun them with almost 100% chance. Equip the Surprising Empowered Isotope-8 on Captain America and use Shield Throw to stun all three bosses. The main threat in this fight are the
Bleeding (3 rounds) - Taking damage every round or after performing hostile actions; This effect can be applied 3 timesBleeding (3 rounds) - Taking damage every round or after performing hostile actions; This effect can be applied 3 times
 Bleeding debuff dealt by Baron Zemo and the
Poisoned (2 turns) - Taking damage every turn; Attack reducedPoisoned (2 turns) - Taking damage every turn; Attack reduced
 Poisoned one dealt by Viper: stun Viper with Falcon's Dive Bomber while tanking with Cap, and repeat this battle setup every possibile time. Using Falcon's Sky-High is also a good idea. Try to dispose of Viper first, and attack Zemo every time he starts concentrating to prevent him from using
The Baron's Mark (2 turns) - Attacking will cause Baron Zemo to counter with a deadly Counter Attack; Can be removed with Recharge; Prevents Counter Attacks and ProtectThe Baron's Mark (2 turns) - Attacking will cause Baron Zemo to counter with a deadly Counter Attack; Can be removed with Recharge; Prevents Counter Attacks and Protect
 The Baron's Mark, which applies
Generalized (2 turns) - Removes effects from Class bonuses; Prevents this character from gaining Class benefitsGeneralized (2 turns) - Removes effects from Class bonuses; Prevents this character from gaining Class benefits
 Generalized other than the homonymous debuff.

Do not use shield guard if you have the Captain with Surprising Empowered Isotope-8 as the Hydra members will take the stun and get recovering immediatly if they are stuned with a counter.

If you're using the Captain Steve Rogers alt, the battle will be different: you can't obviously tank but you can
Depower (1 round) - The next offensive action no longer applies harmful or beneficial effectsDepower (1 round) - The next offensive action no longer applies harmful or beneficial effects
 Depower Zemo and/or Viper, preventing them from dealing their dangerous debuffs.

Additionally, if you already have Falcon recruited and at least at level 9, you can equip the Surprising Empowered Isotope-8 on him instead. Then simply use his level 9 attack to stun all enemies, then the level 2 on the second turn to counter attacks in the next round. Repeat until all Hydra is defeated.

Alternate strategy: Have a Captain America equipped with Surprising Empowered Isotope-8 (The Crowd Control Empowered Isotope-8 instead helps even further, though). During battle, attack with Cap's Shield Throw, Stunning all enemies, then use Falcon's L9 for offensive duty. DO NOT use Shield Guard unless the Hydra heads are
Recovering (Expired next round) - Recently stunned; Can't be stunnedRecovering (Expired next round) - Recently stunned; Can't be stunned
 Recovering, but if you do, attack with Falcon's L2 already bolstered by
Epiphany (2 rounds) - The next attack is guaranteed to be a critical hitEpiphany (2 rounds) - The next attack is guaranteed to be a critical hit
 Epiphany, and when a boss attacks, you have a chance to trigger a distress call for a counter. When one boss remains (possibly Strucker or Viper), using Dive Bomber upon the latter is highly adviseable.

Mission 2 - Ancient Knight[]

Heroic Battle
Meretrix Icon Meretrix Infiltratoricon
Passive: None
Mephisto Icon Mephisto Blastericon
Passive: None
Meretrix Icon Meretrix Infiltratoricon
Passive: None

Heroes Required: Ghost Rider
Appears in: Chapter 6 - When Opportunity Knocks: Mission 2 - Ancient Knight
Potential Gear Reward: Random Deploy Gear, Empowered Iso-8 038Tenacious Empowered Isotope-8
Total Hero Cost: 200 Command point icon

This fight is complicated due to needing to carefully choose when to strike each foe. You need to KO each of the two Meretrix before Mephisto or he will KO them to restore his HP to full. However, the Meretrixes will often use Temptation to give themselves
Hell Hath No Fury - Retaliates when scorned, or attacked.Hell Hath No Fury - Retaliates when scorned, or attacked.
 Hell Hath No Fury which will probably KO you if you hit them with a regular attack. However, they cannot counter Psychic attacks, thus you are safe to use Penance Stare on them at any time. Also, using Highway to Hell on Mephisto will apply
Soulfire (2 rounds) - Taking magic damage every turn; Removes beneficial statuses when appliedSoulfire (2 rounds) - Taking magic damage every turn; Removes beneficial statuses when applied
 Soulfire to the Meretrixes without triggering a counter attack.

Gaining stacks of Effect Icon 001 Green Vengeance is probably best saved for when you are attempting to KO Mephisto as it will be removed each time Mephisto uses Sear.

This fight is extremely easy for a L9 Ghost Rider. Give Ghost Rider the Soothing Rest Empowered Iso-8. For the first two rounds, Mephisto will use Binding Contract on each Meretrix(one for each round) which will apply 4 Sin to them. Once it's Ghost Rider's turn, use his L9 move Burn Out which will give Ghost Rider X stacks of Spirit of Vengeance(X=total # of Sin on all enemies) which will increase his attack. Since Burn Out is a Quick Action you will get another attack. Use Ghost Rider's L2 move Penance Stare to take out the Meretrix with Sin on it. Penance Stare is a psychic attack and shouldn't trigger Temptation. For the next two rounds use Soothing Rest to keep Ghost Rider's health up while Penance Stare recharges. Once it does use it on the second Meretrix. Mephisto shouldn't have any stacks of Sin so Penance Stare would be very ineffective at this time. Keep using Soothing Rest each round and then Burn Out whenever possible. Since the both Meretrix are defeated Mephisto will start to get Sin when he attacks. Once he's reached 4 or 5 Sin use Penance Stare to defeat him.

Mission 3: Dark Complications[]

Heroic Battle
Ares Icon Ares Bruisericon
Passive:
Relentless - Immune to Stun, Exhaustion, Cower and prevention effectsRelentless - Immune to Stun, Exhaustion, Cower and prevention effects
Ten-Thousand-Yard Stare - Chance to preemptively counter enemy attacks with Intimidated and Broken Will, greatly reducing the damage of the incoming attackTen-Thousand-Yard Stare - Chance to preemptively counter enemy attacks with Intimidated and Broken Will, greatly reducing the damage of the incoming attack
God of War - Grants party War Never Changes; Chance to join in on an ally's single-target attack; Chance to retaliate when an ally is hit by single-target attacksGod of War - Grants party War Never Changes; Chance to join in on an ally's single-target attack; Chance to retaliate when an ally is hit by single-target attacks

Heroes Required: War Machine
Appears in: Chapter 6 - When Opportunity Knocks: Mission 3 - Dark Complications
Potential Gear Reward: Random Deploy Gear, Empowered Iso-8 004Tactical Empowered Isotope-8, Empowered Iso-8 013Desperate Empowered Isotope-8
Total Hero Cost: 48 Command point icon

This battle is a 1-on-1 between War Machine and Ares, and it's pretty easy. The most important stats to buff are War Machine's Health and Attack.

Ares will often take the first turn, and his actions are pretty random: the only thing to be careful about is Ares' Art of War, which could be dangerous if used too many times. War Machine should only spam his Repulsor Ray, using
Overcharge - Restores all Stamina; Grants Maximum Charged Capacitors; Next attack drains all StaminaOvercharge - Restores all Stamina; Grants Maximum Charged Capacitors; Next attack drains all Stamina
 Overcharge when low on Stamina and then keep spamming. If Rhodey is well ISO'd, Ares should fall in a few turns, but watch out from Ares'
Bleeding (3 rounds) - Taking damage every round or after performing hostile actions; This effect can be applied 3 timesBleeding (3 rounds) - Taking damage every round or after performing hostile actions; This effect can be applied 3 times
 Bleeding which it may be crucial when Rhodey has low health. Obviously, using an alternate outfit will make things easier. If you're using the Iron Patriot alt (especially the Blaster version) a double/triple 21 Gun Salute, each one with a
Radiation Exposure (3 rounds) - Deals damage every turn; Increases damage taken from energy attacksRadiation Exposure (3 rounds) - Deals damage every turn; Increases damage taken from energy attacks
 Radiation Exposure, will put Ares in serious trouble from the first turn. The Original War Machine alt, anyway, will allow you to use the Overcharge from the beginning (since it does not empty Stamina, with this outfit), and obviously the
Wild Blue Yonder - Calls in a devastating airstrike after 3 roundsWild Blue Yonder - Calls in a devastating airstrike after 3 rounds
 Wild Blue Yonder will allow you to defeat Ares even faster.

Alternate Strategy: by using the Iron Patriot suit you should start with 21-Gun Salute(no Overcharge, just normal) this should put 1 to 2 stacks of Radiation Exposure on Ares. Next turn use Overcharge and Repulsor Beam. In the Iron Patriot suit they give Target Focus and Lock-On and exploit Radiation Exposure and Ares has at least 1 or 2 stacks on him using this method and with the guaranteed crits from Overcharge Ares will fall in two turns in Rhodey is Iso'ed right.

Alternate Strategy #2: Equip the Ionizing A-ISO (buyable in the store for a few Gold) to War Machine's Blade Punch. Just attack Ares with Blade Punch, he shall take a lot of damage due to
Radiation Exposure (3 rounds) - Deals damage every turn; Increases damage taken from energy attacksRadiation Exposure (3 rounds) - Deals damage every turn; Increases damage taken from energy attacks
 Radiation Exposure and the Attack Buffs
High Crits - Increased chance of critical hitsHigh Crits - Increased chance of critical hits
 High Crits and
Ignore Defense - Damage ignores enemy's Defense stat; Attacks penetrate Shield statusesIgnore Defense - Damage ignores enemy's Defense stat; Attacks penetrate Shield statuses
 Ignore Defense. Afterwards, use his L9 followed by Repulsor Ray in order to deal massive damage. This works pretty well with Iron Patriot alt (due to his Repulsor Beam having
Exploit Radiation - Deals extra damage against targets with Radiation ExposureExploit Radiation - Deals extra damage against targets with Radiation Exposure
 Exploit Radiation) and with the Original alt (due to the fact that War Machine does not get
Overheated (1 round) - Can't gain Charged CapacitorsOverheated (1 round) - Can't gain Charged Capacitors
 Overheated upon using his L9 and
Overcharge - Restores all Stamina; Grants Maximum Charged Capacitors; Next attack drains all StaminaOvercharge - Restores all Stamina; Grants Maximum Charged Capacitors; Next attack drains all Stamina
 Overcharge does not fully drain his stamina)

Mission 4: Harvester of Souls[]

Heroic Battle
Satana Icon Satana Infiltratoricon
Passive:
Sinful Thoughts - Chance to gain Sin when attacking; Increases damage done while affected by Sin; Chance to apply Soulfire on all attacks while affected by BaneSinful Thoughts - Chance to gain Sin when attacking; Increases damage done while affected by Sin; Chance to apply Soulfire on all attacks while affected by Bane
Flying - Immune to most ground attacksFlying - Immune to most ground attacks
Dark Pact - Raises stats when affected by Dizzy, Exposed, Slowed, or WeakenedDark Pact - Raises stats when affected by Dizzy, Exposed, Slowed, or Weakened

Heroes Required: Daimon Hellstrom
Appears in: Chapter 6 - When Opportunity Knocks: Mission 4 - Harvester of Souls
Potential Gear Reward: Random Deploy Gear, Empowered Iso-8 039Hellacious Empowered Isotope-8, Empowered Iso-8 021Enticing Empowered Isotope-8
Total Hero Cost: 200 Command point icon

This is another 1-on-1 battle, this time between the infernal siblings Daimon and Satana. Daimon Hellstrom has a unique passive called
Purifier - Purifying Flames gains PurityPurifier - Purifying Flames gains Purity
 Purifier, which allows him to remove his debuffs with
Purifying Flames - Restores Health each turn; Removes and Prevents Debuffs; Does not remove Burning or Dark Void from Daimon HellstromPurifying Flames - Restores Health each turn; Removes and Prevents Debuffs; Does not remove Burning or Dark Void from Daimon Hellstrom
 Purifying Flames. This is actually more a threat than a help, since using Purifying Flames will remove even
Burning (2 rounds) - Taking damage every turn; Defense reduced; Cancelled by chilledBurning (2 rounds) - Taking damage every turn; Defense reduced; Cancelled by chilled
 Burning and
Dark Void (2 rounds) - Taking Magic damage every turn; Accuracy reducedDark Void (2 rounds) - Taking Magic damage every turn; Accuracy reduced
 Dark Void from Daimon. The battle should begin right with Purifying Flames, which will allow Hellstrom to regenerate his health for several turns, then using Cloaked in Shadows and spam From Hell's Heart whenever possible, using Purifying Flames whenever needed. Watch out anyway, because when Satana will be low on health she'll try to cure herself: hit her whenever possible with Daimon's La Petite Mort, keeping her under
Despair (2 rounds) - Removes and prevents resurrection effects while active; Prevents most healing while activeDespair (2 rounds) - Removes and prevents resurrection effects while active; Prevents most healing while active
 Despair and she'll fall pretty quickly.

Mission 5: Clash of Titans[]

Heroic Battle
Inves Icon Inves Blastericon
Passive:
Volatile -Volatile -
The Hood Icon The Hood Infiltratoricon
Passive:
Flying - Immune to most ground attacksFlying - Immune to most ground attacks
Tetrabrach Icon Tetrabrach Scrappericon
Passive:

Heroes Required: Punisher
Appears in: Chapter 6 - When Opportunity Knocks: Mission 5 - Clash of Titans
Potential Gear Reward: Random Deploy Gear, Empowered Iso-8 040Prepared Empowered Isotope-8
Total Hero Cost: 135 Command point icon

In this fight Punisher battles The Hood with a Blaster Demon who can apply
Burning (2 rounds) - Taking damage every turn; Defense reduced; Cancelled by chilledBurning (2 rounds) - Taking damage every turn; Defense reduced; Cancelled by chilled
 Burning and will attack with a suicide blast before he dies and a Scrapper Demon who will apply
Pummeled 3 rounds - Reduces Evasion on every time attackedPummeled 3 rounds - Reduces Evasion on every time attacked
 Pummeled to Punisher. This battle can be tricky but can be made a lot easier with a few pieces of gear. First is the Cleansing EISO, which can remove a debuff each turn. This EISO was almost mandatory for finishing Mockingbird's Heroic Battle so if you have completed that fight there is a good chance you bought it to assist with that battle, if you have it give it to Punisher for this fight. This can become mandatory as the blaster demon in the fight can apply Burning to Punisher and the Scrapper demon can apply Pummeled, both are very bad for this fight and removing them is mandatory. The second is Punisher's Fatal Fender AISO, which gives
Brutal Strike - Damage cannot be prevented by resurrection effectsBrutal Strike - Damage cannot be prevented by resurrection effects
 Brutal Strike to Battle Van (don't give Punisher the Loaded AISO, since it gives a cooldown to Walking Armory). This battle is about turn order and luck. If Punisher goes first (and hope he does) fire off the van right away. With the Fatal Fender AISO and Punisher properly ISO'ed this should take out both of the minions right away, making the fight much easier: the Hood's minions don't have much Health or Defense, so it is quite easy to do this. If you don't have the AISO it can still be done, just much harder. Punisher will need a good amount of Evasion and the first target should be the Blaster, to avoid his Burning debuff. Switch to Tact first and take him out: it should go out in one turn; he will then perform a suicide attack, but it shouldn't cause any long term problems. Next target is the Scrapper Demon: switch to Brusier and use the minigun until the demon falls. This will also grant the
Enraged (1 round) - Increases all stats; Stacks up to 2 timesEnraged (1 round) - Increases all stats; Stacks up to 2 times
 Enraged bonus to Punisher, making the Hood fall much faster.

When it is down to The Hood he'll use a new ability called Dark Metamorphosis, which will change his class at the start of his turn (often Tactician). Simply switch to the counter-class and attack him with Punisher's lv1, and Hood should fall in no time. Due to the potential of having so many class benefits mixed up from constant switching class, Hood should pose no real issue. Depending on when you get your first turn will determine how well this fight will go. The sooner you get your first move, the better your odds are of winning. If all three go before you your chances of winning are slim.

The alternative strategy is to focus on the Hood. The Cleansing Empowered ISO-8 will still be handy. When it's Punisher's turn, switch to Tact and throw Proximity Grenade on the Blaster Demon, giving yourself an extra turn. After that, switch to Scrapper and throws grenade on the Hood. Try to remain Scrapper because it counters all attacks (note that every ranged attack will be countered with Trap Grenade, which has a chance to
Stun (1 turn) - Loses next turn; Reduced chance to dodgeStun (1 turn) - Loses next turn; Reduced chance to dodge
 Stun), except when the Hood is Bruiser: in this case switch to Blaster and use the Migrant.

Premium Mission: Fourth Wall[]

Heroic Battle
Maggia Hitman Icon Maggia Hitman Scrappericon
Passive:
Hair Trigger - Has a chance to counter Ranged attacksHair Trigger - Has a chance to counter Ranged attacks
Bulletproof Jacket - Takes reduced damage from Ranged attacksBulletproof Jacket - Takes reduced damage from Ranged attacks
Bodyguard - See DisambiguationBodyguard - See Disambiguation
Hammerhead Icon Hammerhead Scrappericon
Passive:
Juiced Up - Attacks that would reduce health to 0 will reduce health to 1% insteadJuiced Up - Attacks that would reduce health to 0 will reduce health to 1% instead
Maggia Hitman Icon Maggia Hitman Scrappericon
Passive:
Hair Trigger - Has a chance to counter Ranged attacksHair Trigger - Has a chance to counter Ranged attacks
Bulletproof Jacket - Takes reduced damage from Ranged attacksBulletproof Jacket - Takes reduced damage from Ranged attacks
Bodyguard - See DisambiguationBodyguard - See Disambiguation

Heroes Required: Luke Cage, Iron Fist
Appears in: Chapter 6 - When Opportunity Knocks: Premium Mission: Fourth Wall
Potential Gear Reward: Random Deploy Gear, Empowered Iso-8 002Cracking Empowered Isotope-8, Empowered Iso-8 024Heartfelt Empowered Isotope-8
Total Hero Cost: 38 Command point icon

This battle should require Iron Fist to be at least at level 9 and Luke Cage at least at level 2, but at level 6 it makes the battle easier. First, you need Iron Fist to use K'un L'un Combo on one of the Maggia, then Luke Cage should use
Bodyguard - See DisambiguationBodyguard - See Disambiguation
 Bodyguard, then Brawl on the other. If you get Luke Cage first, attack one of the Maggia, then with Iron Fist aim for the same Maggia that protected from Luke Cage, which will make the other Maggia protect that attack. Because of the debuffs plus Bodyguard, Luke Cage will pre-counter the Maggia with Brawl, ensuring their demise even more quickly. Then Iron Fist should use heart of Shou-Lao and the move "The Iron Fist" on any of the Maggia. That should kill off one of the Maggia. Luke Cage should then use Bodyguard and Brawl on the other Maggia (make sure to use Bodyguard every round): since Luke Cage will take pratically all of the enemies' attacks, be sure to use Iron Fist's Healing Chi on him whenever needed (also useful to remove the dangerous
Iso-8 Corruption (3 turns) - Taking damage every turn; All Stats Reduced; This effect can be applied 3 timesIso-8 Corruption (3 turns) - Taking damage every turn; All Stats Reduced; This effect can be applied 3 times
 Iso-8 Corruption debuff dealt by Hammerhead). Once the Maggia are gone, the battle is easy from there: Hammerhead, due to his passive, has to be finished off with either Luke Cage's L2 move (which has
Brutal Strike - Damage cannot be prevented by resurrection effectsBrutal Strike - Damage cannot be prevented by resurrection effects
 Brutal Strike, now) or Heroic Age Iron Fist's L2 after activating Hidden Potential. Obviously Heroic Age Iron Fist's alt will make the battle easier, but it is recommended using the same strategy even with the alternate outfit. The Bruiser variant being the obvious choice but it won't be necessary as this fight is pretty simple with or without this suit. If all three enemies have
Combo Setup (3 turns) - The next unarmed attack against this target deals extra damageCombo Setup (3 turns) - The next unarmed attack against this target deals extra damage
 Combo Setup on them Luke Cage alone can win this fight with counters from bodyguard and Iron Fist's only real duty is to heal him. Alternate Strategy: If you have A-Iso Yellow 089Ferric Augmented Iso-8 on Iron Fist, this battle would be slightly easier. You seize the advantage by using Luke's L6 for defensive duty and healing Luke Cage with Iron Fist's L6 (when needed), which grants
Rising Up - Has a chance to gain Focused, Fortified, Agile, or StrengthenedRising Up - Has a chance to gain Focused, Fortified, Agile, or Strengthened
 Rising Up, bolstering his offensive/defensive power. This works to perfection, especially if Luke has
Bodyguard - See DisambiguationBodyguard - See Disambiguation
 Bodyguard and all the foes have
Combo Setup (3 turns) - The next unarmed attack against this target deals extra damageCombo Setup (3 turns) - The next unarmed attack against this target deals extra damage
 Combo Setup.
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