Epic Bosses are Villains that will only appear once all threats and Deploys in a Mission have been completed. Some of the Deploys require a hero of a specific Class or a specific Hero to be completed.
If any of the Deploys have not been completed when the last battle is done, the Epic Boss will not appear. To prevent this, players should do the Deploy Mission as soon as it appears.
Heroic Battles and Incursions do not have to be completed for the Epic Boss to appear.
Story: Season 1 Mission Epic Bosses
Chapter 2 Mission 3 - Elektra
- Location: Chapter 2, Mission 3
- Deploy Requirements: Scrapper and Black Cat
- Team-Up: Daredevil
- Epic Drop: Grecian Sai or Custom Grecian Sai.
- Waves: 1
- Wave 1: Hand Shadow, Elektra and Hand Shadow
- Strategy: Elektra is supported by 2 Scrappers and will counter-attack all attacks with Internal Bleeding effect. But don't let this stop you from bringing your best scrapper or bruiser.
- Total Energy Cost: 90 Energy if both the Boss and the Mini Boss are defeated together.
Chapter 3 Mission 5 - Dr. Doom
- Location: Chapter 3, Mission 5
- Deploy Requirements: Blaster, Tactician, Black Widow and Spider-Man
- Team-Up: Hawkeye
- Epic Drop: The Doombringer.
- Waves: 1
- Wave 1: Dr. Doom, Dr. Doom and Dr. Doom
- Strategy: Instead of Dr. Doom himself, players will be facing three Doombots. All Doombots are Blasters and can share health by draining the health of another Doombot to heal itself. It is best advised to focus on one Doombot before moving on to the next Doombot. Repeat until all the Doombots are defeated.
- Total Energy Cost: 80 Energy if both the Boss and the Mini Boss are defeated together.
Chapter 4 Mission 4 - Magneto
- Location: Chapter 4, Mission 4
- Deploy Requirements: Scrapper and Storm
- Team-Up: Invisible Woman
- Epic Drop: Magnetic Field Generator or Custom Magnetic Field Generator - this Epic Item is touted as being one of the best items in the game so it's very much worth farming this mission to get this item (the xp is decent too).
- Waves: 1
- Wave 1: Magneto
- Strategy: Magneto's attacks leaves the target with a positive or negative charge. Magneto also uses a Positron Shield (positive charge) or an Electron Shield (negative charge). Attacks with the same charge will bounce off, while attacks with the opposite charge of the shield will pass right through. It is best to use a hero or items that penetrate shield such as War Machine's Blade Punch or Black Panther's Anti-Metal Claws as then players won't have to worry about the charge. Or use a hero with Shield Breaker ability. After Shield Breaker applied Magneto tries to replenish shield but fails. After then all you have to do is hit him hard as you can.
- Total Energy Cost: 70 Energy if both the Boss and the Mini Boss are defeated together.
Chapter 5 Mission 3 - Loki
- Location: Chapter 5, Mission 3
- Deploy Requirements: Scrapper, Blaster and Wolverine
- Team-Up: Thing
- Epic Drop: Norn Stone or Custom Norn Stone.
- Waves: 3
- Wave 1: Loki
- Wave 2: Loki, Loki and Loki
- Wave 3: Loki
- Strategy:
- Wave 1: Loki has a debuff that will heal him instead of damage him when you attack him while those effects are active.
- Wave 2: Loki has two decoys; the real Loki has a green symbol instead of a red one. Attack that Loki over and over (even with attacks that don't deal damage such as a Laser Spotter) and you will trigger Harmful Discovery, which will deal damage to all three Loki. If you attack the wrong Loki, you will heal him instead of damaging him.
- Wave 3: Loki, same as Wave 1.
- Total Energy Cost: 100 Energy if you defeat the Boss + Mini Boss together.
Chapter 6 Mission 3 - Doctor Octopus
- Location: Chapter 6, Mission 3
- Deploy Requirements: Scrapper, Bruiser and Luke Cage
- Team-Up: Spider-Woman
- Epic Drop: Electrostatic Arm or Custom Electrostatic Arm.
- Waves: 1
- Wave 1: Doctor Octopus
- Strategy: Doctor Octopus is pretty easy for an Epic Boss. The only unusual thing is that he transfers a "hot potato" ISO virus at you once in a while and boosts his companions. The virus can be sent back by attacking so it's pretty simple to get rid of. Just make sure that you transfer it right before it expires as it inflicts a lot of damage and gives a lot of status effects.
- Total Energy Cost: 100 Energy if you defeat the Boss + Mini Boss together.
Chapter 7 Mission 3 - Green Goblin
- Location: Chapter 7, Mission 3
- Deploy Requirements: Scrapper, Tactician and Spider-Man
- Team-Up: Black Cat
- Epic Drop: Goblin Glider or Custom Goblin Glider
- Waves: 1
- Wave 1: Green Goblin
- Strategy: Green Goblin is on his own and is a Scrapper. A solid Bruiser team should do the trick.
- Total Energy Cost: 100 Energy if you defeat the Boss + Mini Boss together.
Chapter 8 Mission 5 - The Hood
- Location: Chapter 8, Mission 5
- Deploy Requirements: Tactician, Blaster, and Hawkeye
- Team-Up: Spider-Woman
- Epic Drop: Possessed Pistol or Custom Possessed Pistol
- Waves: 3
- Wave 1: Hydro-Man, The Hood and Crimson Cowl
- Wave 2: Constrictor, The Hood and Madame Masque
- Wave 3: Jack O'Lantern, The Hood and Grey Gargoyle
- Strategy: There will be three waves with The Hood as a recurring leader. Most of these opponents are immune to stun;
- Wave 1: The Hood (Infiltrator), supported by Hydro-Man (Bruiser) and the Crimson Cowl (Infiltrator)
- Wave 2: The Hood (Infiltrator), supported by Madame Masque and Constrictor, whom are both Tacticians
- Wave 3: The Hood (Infiltrator), supported by Jack O'Lantern (Blaster) and the Grey Gargoyle (Scrapper). They have very nasty debuffs especially Jack O'Lantern.
- Focus on targeting each boss individually and taking them out quickly and you should be able to prevail. Bring one scrapper and damage the Hood a bit, he will vanish if his health is reduced, returning again on the next wave (even if you manage to kill him on one wave, he will still come back on the next one).
- Total Energy Cost: 90 Energy if you defeat the Boss + Mini Boss together.
Chapter 9 Mission 4 - M.O.D.O.K.
- Location: Chapter 9, Mission 4
- Deploy Requirements: Tactician, Invisible Woman, Rogue and Thing
- Team-Up: She-Hulk
- Epic Drop: Only For Killing or Custom Only For Killing
- Waves: 1
- Wave 1: M.O.D.O.K.
- Strategy: He is a blaster and he is alone, bringing multiple tacticians will speed up the battle and give you an edge
- Total Energy Cost: 110 Energy if you defeat the Boss + Mini Boss together.
Chapter 10 Mission 4 - Dormammu
- Location: Chapter 10, Mission 4
- Deploy Requirements: Spider-Woman, Blaster, and Scrapper
- Team-Up: Thor
- Epic Drop: Touch of Flame and Shadow or Custom Touch of Flame and Shadow
- Waves: 3
- Strategy: Dormammu is a Generalist with the Passive Ability Relentless, so trying to stun is useless. Just take your most powerful weapons for your Agent and your most powerful hero to fight him.
- You may bring heroes that use psychic attacks because there are no Mindless Ones present in this battle. To defeat Dormammu, use classes that counter each other because Dormammu can change class.
- Total Energy Cost: 100 Energy if you defeat the Boss + Mini Boss together.
Chapter 11 Mission 3 - Baron Zemo
- Location: Chapter 11, Mission 3
- Deploy Requirements: Phoenix, Bruiser, Infiltratror and any Hero
- Team-Up: Nightcrawler
- Epic Drop: Sword of the Barony or Custom Sword of the Barony.
- Waves: 3
- Wave 1: Hydra Vanguard, Baron Zemo and Hydra Judicator .
- Wave 2: Power Armor and Power Armor .
- Wave 3: Hydra Rampart, Baron Zemo and Hydra Rampart
- Strategy: None
- Total Energy Cost: 100 Energy if you defeat the Boss + Mini Boss together.
Chapter 12 Mission 2 - Viper
- Location: Chapter 12 - Mission 2
- Deploy Requirements: Kitty Pryde
- Team-Up: Captain America
- Epic Drop: Spitting Viper or Custom Spitting Viper.
- Waves: 2
- Wave 1: Power Armor, Viper and Power Armor
- Wave 2: Viper
- Strategy: Wave 1:Take out the power armor first (tip:best if you bring out heroes immune to poison & bleeding)
- Wave 2:just attack viper with all your might
- Total Energy Cost: 20 Energy if you defeat the Boss + Mini Boss together.
Story: Season 2 Mission Epic Bosses
Chapter 1 Mission 4 - Doctor Octopus
- Location: Chapter 1, Mission 4
- Deploy Requirements: Black Knight, Psylocke & Union Jack
- Team-Up: Captain Britain (Optional)
- Epic Drop: Barber's Razor or Stropped Razor
- Waves: 1
- Wave 1: SC-Beta, Doctor Octopus & SC-Beta
- Strategy: At one point of the battle (usually in his first turn), Doctor Octopus will use a highly damaging move called "Hero Dissecation". Use some powerful healing item after that move (I recommend Shawarma or Gold Nugget) and then, attack. The SC-Beta shouldn't be such a problem. But still, bring your most powerful Bruiser, an Infiltrator and a Generalist for an easier win. Bringing a Blaster is not recommended, as Doctor Octopus is a Tactitian.
- Total Energy Cost:
Chapter 1 Mission 6 (Premium) - M.O.D.O.K.
- Location: Chapter 1, Mission 6
- Deploy Requirements: Scarlet Witch, Spider-Woman & Rogue
- Team-Up: Gambit (Optional)
- Epic Drop: Bel Nemeton or Glas Tann
- Waves: 3
- Wave 1: Fire Chief, Fire Chief & Fire Chief
- Wave 2: Director, Director & Director
- Wave 3: Scientist, M.O.D.O.K. & Scientist
- Strategy: The first two waves aren't really hard and passing them should not be a problem. On the last wave, a Tactitian could really come in handy, because M.O.D.O.K. is a Blaster. His Psycho-8 (move that applies Mental Anguish) is the most annoying one. Just watch out for his attacks and you'll be fine.
- Total Energy Cost: 80 Energy if you defeat the Boss + Mini Boss together.
Chapter 2 Mission 4 - Red Skull
- Location: Chapter 2, Mission 4
- Deploy Requirements: Thing, Thundra & Wolverine
- Team-Up: Hank Pym (Optional)
- Epic Drop: 500 GW Power Supply or 500 GW Power Supply
- Waves: 1
- Wave 1: Chiyome, Red Skull & Chiyome
- Strategy: Just bring your best infiltrator and scrapper.
- Total Energy Cost:
Chapter 2 Mission 6 (Premium) - Sugar Man
- Location: Chapter 2, Mission 6
- Deploy Requirements: Iron Man, Nightcrawler & Tigra
- Team-Up: Scarlet Witch (Optional)
- Epic Drop: Revolt 4 or Revolt 5
- Waves: 1
- Wave 1: Hydra Rampart, Sugar Man & Hydra Rampart
- Strategy: Bring a fast blaster like Human Torch to bring down the Ramparts, then get your best scrapper to pummle Sugar Man.
- Total Energy Cost:
Chapter 3 Mission 5 - Ultron
- Location: Chapter 3, Mission 5
- Deploy Requirements: Beast, Ghost Rider & Ms. Marvel
- Team-Up: Fantomex (Optional)
- Epic Drop:
- Waves: 1
- Wave 1: Ultron
- Strategy: None
- Total Energy Cost:
Chapter 3 Mission 6 (Premium) - Sin
- Location: Chapter 3, Mission 6
- Deploy Requirements: Colossus, Daredevil & Invisible Woman
- Team-Up: Punisher (Optional)
- Epic Drop: Combat Knife or Tactical Knife
- Waves: 1
- Wave 1: Power Armor, Sin & Hydra Vanguard
- Strategy: None
- Total Energy Cost:
Chapter 4 Mission 3 - Destroyer
- Location: Chapter 4, Mission 3
- Deploy Requirements: Emma Frost, Hercules & Thor
- Team-Up: Valkyrie
- Epic Drop: Asgardian Gauntlet or Tempered Asgardian Gauntlet
- Waves: 1
- Wave 1: Destroyer
- Strategy: Just bring your best Blasters (Havok is probably the best for this guy), just use Lost Pages of Vishanti if you are inflicted with Cursed Mirror.
- Total Energy Cost:
Chapter 4 Mission 6 (Premium) - Venom
- Location: Chapter 4, Mission 6
- Deploy Requirements: Hank Pym, Ms. Marvel & Wasp
- Team-Up: Black Panther
- Epic Drop: Incinerator Unit or High Capacity Incinerator Unit
- Waves: 1
- Wave 1: Venom
- Strategy: Another lone bruiser, either you bring Pym to complement Panther and rip Venom apart or just bring your best blaster.
- Total Energy Cost:
Chapter 5 Mission 5 - Enchantress
- Location: Chapter 5, Mission 5
- Deploy Requirements: Vision, Fandral & Quicksilver
- Team-Up: Thor (Optional)
- Epic Drop: Huldran's Call or Huldran's Powerful Call
- Waves: 1
- Wave 1: Enchantress, Dark Elf Cannoneer & Jotun Ice-Shaper
- Strategy:
- Total Energy Cost:
Chapter 5 Mission 6 (Premium) - Man-Ape
- Location: Chapter 5, Mission 6
- Deploy Requirements: Punisher, Havok & Hulk
- Team-Up: Hercules
- Epic Drop: Wakandan Rungu or [[|]]
- Waves: 3
- Wave 1: Hydra Pyro,Hydra Vanguard & Hydra Pyro
- Wave 2: Hunter, Hunter & Warrior
- Wave 3: Man-Ape
- Strategy:
- Total Energy Cost:
Chapter 6 Mission 3 - Green Goblin
- Location: Chapter 6, Mission 3
- Deploy Requirements: Black Knight, Captain Britain and Fantomex
- Team-Up: Iron Fist
- Epic Drop:
- Waves:
- Strategy:
- Total Energy Cost:
Chapter 6 Mission 6 (Premium) - Savin
- Location: Chapter 6, Mission 6
- Deploy Requirements: Ares, Black Widow and Punisher
- Team-Up: Deadpool
- Epic Drop: Laprov or Laprov!
- Waves: 1
- Strategy:
- Total Energy Cost:
Chapter 7 Mission 2 - Mysterio
- Location: Chapter 7, Mission 2
- Deploy Requirements: Fandral, Hogun and Mockingbird
- Team-Up: Daredevil
- Epic Drop: Mysterium Mirror or Mysterium Manifold
- Waves: 2
- Wave 1: Maggia Hitman and Maggia Assassin
- Wave 2: Maggia Hitman, Mysterio & Maggia Captain
- Strategy:
- Total Energy Cost:
Chapter 7 Mission 6 (Premium) - Skadi
- Location: Chapter 7, Mission 6
- Deploy Requirements: Agent Venom, Spiral and X-23
- Team-Up: Any heroes
- Epic Drop: Brannhammer or Brannblodhammer
- Waves: 1
- Wave 1: Onna Bugeisha Skadi & Onna Bugeisha
- Strategy:
- Total Energy Cost:
Special Operations Mission Epic Bosses
Spec Op 1 Mission 1 - Hammerhead
- Location: Special Ops 1, Mission 1
- Deploy Requirements: Tactician, Infiltrator, Black Widow and Spider-Woman.
- Team-Up: Black Widow
- Epic Drop: The Toolbox
- Waves: 3
- Wave 1: Scientist, Maggia Assassin and Fire Chief
- Wave 2: Fire Chief, Maggia Captain and Fire Chief
- Wave 3: Maggia Hitman, Hammerhead and Maggia Assassin
- Strategy: None.
Spec Op 2 Mission 3 - Mystique
- Location: Special Ops 2, Mission 3
- Deploy Requirements: Colossus, Phoenix and Scarlet Witch
- Team-Up: Emma Frost
- Epic Drop: The Bishop.
- Waves: 3
- Wave 1: Hellfire Elite (Infiltrator), Mystique and Hellfire Elite (Infiltrator)
- Wave 2: Hellfire Elite (Blaster), Mystique and Hellfire Elite (Blaster)
- Wave 3: Hellfire Elite (Tactician), Mystique, Hellfire Elite (Tactician)
- Strategy: None.
Spec Op 3 Mission 3 (X-Men Side) - Iron Man
- Location: Special Ops 3, Mission 3
- Deploy Requirements: Gambit, Nightcrawler and Rogue
- Team-Up: Cyclops (Optional)
- Epic Drop: Arc Reactor Charge
- Waves: 1
- Wave 1: Iron Man
- Strategy: He is a Blaster, so you should consider using atleast Emma Frost or War Machine. Also use every piece of Psychic Energy Attack gear you got from the Special Operation.
- Note: Iron Man starts the fight with an Energized Shield .
Spec Op 3 Mission 3 (Avengers Side) - Phoenix
- Location: Special Ops 3, Mission 3
- Deploy Requirements: Black Panther
- Team-Up: Captain America (Optional)
- Epic Drop: Cosmic Flame
- Waves: 1
- Wave 1: Phoenix
- Strategy: Phoenix is a Blaster with Psychic Energy Attack abillities, do not use Shield or Protect abilities, as her attacks will ignore defensive abillities. A Relentless Boss, use your two best Tacticians.
- Note: Phoenix takes two turns each round and can change that into four or three turns if she uses or overuses Phoenix Force.
Spec Op 4 Mission 2 - Dormammu
- Location: Special Ops 4, Mission 2.
- Deploy Requirements: Hercules, Quicksilver, Gambit & Daredevil
- Team-Up: Dr. Strange (Optional)
- Epic Drop:Frozen Hell
- Waves: 3
- Wave 1: Mindless One, Dormammu and Mindless One
- Wave 2: Mindless One, Dormammu and Mindless One
- Wave 3: Mindless One, Dormammu and Mindless One
- Strategy: Dormammu is a Generalist with the Passive Ability Relentless, so trying to stun is useless. Just take your most powerful weapons for your Agent and your most powerful hero to fight him.
- Don't bring heroes using psychic attack and try to use a hero that is immune to burning, chilled etc because Mindless Ones can deal high damage with the stare effect. To kill Dormammu, use classes that counter each other because Dormammu can change class.
Spec Op 5 Mission 1 - Destroyer
- Location: Special Ops 5, Mission 1.
- Deploy Requirements: Beast, Kitty Pryde, Storm and Wolverine
- Team-Up: Valkyrie (Optional)
- Epic Drop: Monstrosity
- Waves: 1
- Wave 1: Destroyer
- Strategy: Taking two heroes that are Blasters and deal heavy damage can destroy him in one or two turns.
Spec Op 6 Mission 2 - Living Pharaoh
- Location: Special Ops 6, Mission 2.
- Deploy Requirements: Nightcrawler and Phoenix
- Team-Up: Havok (Optional)
- Epic Drop: 12 Magnetic Lockboxes
- Waves: 1
- Wave 1: Living Pharaoh
- Strategy: None.
Spec Op 6 Mission 3 - Green Goblin
- Location: Special Ops 6, Mission 3
- Deploy Requirements: Beast, Deadpool and Tigra
- Team-Up: Mr. Fantastic (Optional)
- Epic Drop: GG Prototype or 12 Magnetic Lockboxes
- Waves: 1
- Wave 1: Green Goblin
- Strategy: Green Goblin is on his own and is a Scrapper. A solid Bruiser team should do the trick.
Spec Op 7 Mission 3 - Dr. Doom
- Location: Special Ops 7, Mission 3
- Deploy Requirements: Cable, Spider-Man and Wasp
- Team-Up: Hank Pym (Optional)
- Epic Drop: Servoguard Programming Interface
- Waves: 1
- Wave 1: Dr. Doom
- Strategy: Dr. Doom is on his own and is a Blaster. Just bring 2 your good Tacticians and they should do the trick.
- Note: He has 3 turns in every round.
Spec Op 8 Mission 1 - Loki
- Location: Special Ops 8, Mission 1
- Deploy Requirements: Psylocke, Captain Britain and Black Knight
- Team-Up: Scarlet Witch (Optional)
- Epic Drop: Staff of Mischief
- Waves: 1
- Wave 1: Jotun Chieftain, Loki and Jotun Chieftain.
- Strategy: Loki is with two Scrapper class enemy's and you'r stuck with the scarlet witch for team-up get a solid Bruiser to pick them off and use your Enraged Bruiser to wrap Loki up.
Spec Op 9 Mission 2 - Iron Patriot Armor
- Location: Special Ops 9, Mission 2
- Deploy Requirements: Punisher, Union Jack and War Machine
- Team-Up: Rescue (Optional)
- Epic Drop: Second Amendment
- Waves: 1
- Wave 1: Selene Sentinel , Iron Patriot Armor and Selene Sentinel.
- Strategy: The Selene Sentinels are Scrappers so no Infiltrator class character but a solid Bruiser helps, try focusing on the Sentinels one at a time after one is down take out the other one. only then focus on Savin, use Rescue 4th skill to remove the Countermeasure Protocol the sentinel apply on the team. If you get the first turn and have a chance, Savin first move will usually be Full Overcharge followed by a 21-Gun Salute applying 3 Radiation Exposure charges on your party knowing this apply a shield using MFG and gain a fast lead on the enemy after that he's pretty much defeated wait for a turn.
Spec Op 10 Mission 1 - Baron Zemo
- Location: Special Ops 10, Mission 1
- Deploy Requirements: Black Cat , Thundra and X-23
- Team-Up: Vision (Obligatory)
- Epic Drop: Adhesive X Launcher
- Waves: 2
- Wave 1: Power Armor, Baron Zemo and Hydra Judicator.
- Wave 2: Hydra Rampart, Baron Zemo and Power Armor.
- Strategy: Power Armor is a Generalist and protecting so taking him out should be first move. Baron Zemo is a Tactician so bring good Infiltrators (Swashbuckler Nightcrawler is good because he's Stealthy and inflicts bleeding). Hydra Judicator is a Blaster so he's should not be a problem. In Wave 2, you will face same enemies expect Hydra Judicator is changed to Hydra Rampart, who is Bruiser and protecting too. Vision is a team-up, so using him is a good tactic. First using him as Inf in wave 1 and after defeating Power armor in wave 2, use Vision's Blaster attacks on Hydra Rampart.
Spec Op 11 Mission 2 - Mephisto
- Location: Special Ops 11, Mission 2
- Deploy Requirements: Fantomex , Iron Fist and Scarlet Witch
- Team-Up: Satana (Optional)
- Epic Drop: Hammering Nail
- Waves: 1
- Wave 1: Praefectus, Mephisto and Cusptero.
- Strategy: Mephisto comes with a Tactician demon and a Bruiser demon to support him so there is nothing stopping you from bringing two of your best tacticians. Focus on taking out his demon allies first or he will use them to heal himself, then hit him as hard as you can and he will eventually flee.
Spec Op 12 Mission 2 - Venom
- Location: Special Ops 12, Mission 2
- Deploy Requirements: Thor , Hercules and Shatterstar
- Team-Up: Ares (Optional)
- Epic Drop: Void Generator
- Waves: 2
- Wave 1: Tactician, Infiltrator & Tactician
- Wave 2: Tactician, Venom & Blaster
- Strategy: None
Spec Ops 13 Mission 2 - Dormammu
- Location: Spec Ops 13, Mission 2
- Deploy Requirements: Psylocke, Red Hulk & Wasp
- Team Up: Dr. Strange (Optional)
- Epic Drop: Twisted Gift
- Waves: 1
- Wave 1: Mindless One, Dormammu & Mindless One
- Strategy: None
Spec Ops 14 Mission 2 - Malekith
- Location: Spec Ops 14, Mission 2
- Deploy Requirements: Mockingbird, Valkyrie & She-Hulk
- Team Up: Heimdall (Optional)
- Epic Drop: Darkness
- Waves: 3
- Wave 1: Dark Elf Duskguard, Malekith & Dark Elf Duskguard
- Wave 2: Dark Elf Duskguard, Dark Elf Duskguard & Dark Elf Duskguard
- Wave 3: Malekith
- Strategy: None
Spec Op 15 Mission 1 (Heroes Side) - Constrictor
- Location: Special Ops 15, Mission 1
- Deploy Requirements: Bishop, Spider-Man & Hawkeye
- Team-Up: Captain Britain (Optional)
- Epic Drop: Serpentine
- Waves: 1
- Wave 1: Constrictor & Taskmaster
- Strategy: None.
Spec Op 15 Mission 1 (Villains Side) - Captain Britain
- Location: Special Ops 15, Mission 1
- Deploy Requirements: Black Cat, Emma Frost and Black Widow
- Team-Up: Constrictor (Optional)
- Epic Drop: Britannic Sceptre
- Waves: 1
- Wave 1: Captain Britain & Spider-Man
- Strategy: None
Spec Op 16 Mission 1 - Sugar Man
- Location: Spec Op 16 Mission 1
- Deploy Requirements: Colossus, Havok & Spiral
- Team-Up: Any heroes
- Epic Drop: Memento Mori
- Waves: 1
- Strategy: None
Spec Op 17 Mission 3 - Red Skull
- Location: Spec Op 17 Mission 3
- Deploy Requirements: Fandral, Punisher & Red Hulk
- Team-Up: Captain America
- Epic Drop: Crimson Crusher
- Waves: 1 (Captain America fighting alone)
- Wave 1: Red Skull
- Strategy: You can consider to either react to what the Red Skull do in the following way: Energise-Neutralised, Critical Mass-Impaired, Cosmic Efflux-Depower and Flanked for anything else. Alternatively just keep Depowering him works too.
- Waves: 1 (Assist Captain America)
- Wave 1: Power Armor, Red Skull and Power Armor
- Strategy: Nothing is stopping you to bring your best infiltrator (Pestilence is pretty good if you have him, his L9 can corner)
Spec Op 18 Mission 3 - Green Goblin
- Location: Special Ops 18, Mission 3
- Deploy Requirements: Agent Venom, Gamora and Ms. Marvel
- Team-Up: Spider-Man
- Epic Drop: Gaseous Glider
- Waves: 2
- Wave 1: BR-Delta, BL-Delta & SC-Delta
- Wave 2: Green Goblin & BL-Delta
- Strategy:
Spec Op 19 Mission 2 - Bastion
- Location: Special Ops 19, Mission 2
- Deploy Requirements: Daimon Hellstrom, Hogun and Nightcrawler
- Team-Up: Omega Sentinel
- Epic Drop: Calculated Response
- Waves: 1
- Wave 1: Prime Sentinel, Bastion & Prime Sentinel
- Strategy:
Spec Op 20 Mission 3 - Skadi
- Location: Special Ops 20, Mission 3
- Deploy Requirements: Ares, Phoenix and Rocket Raccoon
- Team-Up: Rocket Raccoon
- Epic Drop: Galactic Crusher
- Waves: 1
- Wave 1: Skadi
- Strategy:
- Restricted: Only Guardians of the Galaxy members can join the battle.
Spec Op 21 Mission 3 - M.O.D.O.K.
- Location: Special Ops 21, Mission 3
- Deploy Requirements: Drax, Groot and Tigra
- Team-Up: Tigra
- Epic Drop: Cybernetic Glaive
- Waves: 2
- Wave 1: Scientist & Director
- Wave 2: Firefighter, M.O.D.O.K. & Scientist
- Strategy:
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