- Doctor Doom gains when performing Magic actions.
- Steal Essence - Can only proc and gain on successful attacks.
- According to Justin Woods the reason for Doctor Doom joining hero team will be revealed in comics.
- Dr Doom has three themed gear: , , and .
- As a Spec Op Epic Boss, Dr. Doom takes 3 actions per round.
- According to Justin Woods in Twitter Live Q&A, Doctor Doom did not kill Cassie Lang in the Marvel Gaming Universe.
- Doctor Doom's Doom entry on his Team-Up section in his Bio will display whatever the players have inputted for their Agent's name.
- Doom possibly references the Incursions in Chapter 12 - Mission 6, where he says "I would have saved this world from the others, and now we will all suffer." The Incursions are also the reason that he joins the agent.
- Doom is the hero with the largest number of Heroes being involved in his recruitment dialogue because of Captain America, Thing, Mr. Fantastic, Nick Fury, Tony Stark and Professor X.
- Action 3 shares cooldown.