- The Destroyer is the 2nd Generalist Lockbox hero. The 1st being Taskmaster.
- The Destroyer has 6 themed items: , , , , , and .
- Players can have the hero version of him fight the villain version in Spec Ops 24.
- The Destroyer, Black Bolt and Groot are the only heroes to have their recruitment dialogues require another hero to talk for them (Groot can talk, but Rocket Raccoon is translating his words).