"Former enemies and rivals begin to band together as New York's villains realize the potential of Iso-8. And the more you learn about who's really pulling the strings, the more all signs point to Latveria..." — Chapter Briefing
"St. Patrick's cathedral is under assault by Servo Guards, typically Doctor Doom's robotic soldiers.Work with Luke Cage to find out what's behind the attack." — Mission Preview
Unlock Requirements: Recruit 6 Heroes Complete 1 Star Mastery in Chapter 2 - Mission 5 Acquire a total of 15 Mastery Stars
"Doctor Doom has to wait as the Maggia wreak havoc at the Brooklyn Bridge. The Fantastic Four's Thing is on hand to help shut down these Iso-8 enhanced mobsters." — Mission Preview
Must finish ALL battles and deploys before the Epic Boss will appear Team-Up:Hawkeye(Obligatory) Epic Boss Drop:The Doombringer Challenge Mode Boss Drop:The Doombringer
"Spider-Man's arch-nemesis Dr. Octopus has taken over the U.S.S. Intrepid. How about if you help the friendly neighborhood hero put Ock on ice?" — Mission Preview