"The Effects of Iso-8 Exposure begin to make everyday villains capable of taking on Earth's mightiest heroes. As S.H.I.E.L.D. tries to uncover why seeming rivals are coordinating their efforts, you'll need to continue developing your leadership skills and combat abilities."
— Chapter Briefing

Mission 1 - In the Family Edit

In the Family Mastery Stars Score Level 0 9 9,000 11 224,000 13 448,000 15 896,000 17 1,792,000 Agent's

"When the Maggia see chaos, they see opportunity. And when they see Iso-8, they see dollar signs. It's just business. "
— Mission Preview

Unlock Requirements:
Recruit 4 Heroes
Complete 1 Star Mastery in Chapter 1 - Mission 5
Acquire a total of 7 Story Mastery Stars

Location: Little Italy
Team-Up: She-Hulk

Low: x2
Medium: x3
High: x2

Enemies Maggia Bodyguard Passive: Maggia Grunt Passive: n/a Maggia Henchman Passive: n/a Maggia Thug Passive: n/a Maggia Duelist Passive: Maggia Gunman Passive: n/a Maggia Hitman Passive:

Minimum Cleared: 4
Team-Up: She-Hulk (Optional)

Mini-Boss Maggia Gunman Passive: n/a Sandman Passive:

Minimum Cleared: 5
Team-Up: She-Hulk
Boss Drops: Knuckle Sting, Batstone 2.357 Minigun
Challenge Mode Boss Drop: Custom Frank Castle Special

Boss Hammerhead Passive: Maggia Hitman Passive:

Boss + Mini-Boss Hammerhead Passive: Sandman Passive: Maggia Hitman Passive:

Requirement: Thing
Duration: 2 Battles

Requirement: Any Hero
Duration: 1 Battle

Requirement: Any Hero
Duration: 1 Battle

Mission 2 - The Sound of Feathers Ruffling Edit

The Sound of Feathers Ruffling Mastery Stars Score Level 0 10 9,000 12 205,000 14 410,000 16 820,000 18 1,640,000 Agent's

"Take a crazed techno-terrorist group. Add a mad scientist who thinks he's a bird. What do you end up with? A problem SHIELD needs fixed."
— Mission Preview

Unlock Requirements:
Own an Upgraded Jet
Complete 1 Star Mastery in Chapter 2 - Mission 1

Location: Bellevue Hospital
Team-Up: Spider-Man

Low: x2
Medium: x2
High: x2

Enemies Biotechnician Passive: n/a Commander Passive: Physicist Passive: n/a Bioterrorist Passive: n/a Guard Passive: n/a

Minimum Cleared: 3
Team-Up: Spider-Man

Mini-Boss Crimson Dynamo Passive: n/a Physicist Passive: n/a

Minimum Cleared: 5
Team-Up: Spider-Man
Boss Drops: Pyro-Tonfa, Third Law Nullifier
Challenge Mode Boss Drop: Custom M616 Combat Shotgun

Boss Wave 1 Guard Passive: n/a Guard Passive: n/a Guard Passive: n/a Wave 2 Vulture Passive: n/a Biotechnician Passive: n/a

Boss + Mini-Boss Wave 1 Guard Passive: n/a Guard Passive: n/a Guard Passive: n/a Wave 2 Vulture Passive: n/a Crimson Dynamo Passive: n/a Biotechnician Passive: n/a

Requirement: Any Hero
Duration: 1 Battle

Requirement: Tactician
Duration: 2 Battles

Requirement: Ms. Marvel
Duration: 1 Battle

Mission 3 - Step into the Shadows Edit

Step into the Shadows Mastery Stars Score Level 0 11 9,000 13 328,000 15 656,000 17 1,312,000 19 2,624,000 Agent's

"Ninjas in Hell's Kitchen? Yes. But they're not looking for Iso-8. Or are they...?"
— Mission Preview

Unlock Requirements:
Complete 1 Star Mastery in Chapter 2 - Mission 2

Location: Hell's Kitchen
Team-Up: Daredevil

Low: x2
Medium: x3
High: x2

Enemies Hand Assassin Passive: n/a Hand Scorpion Passive: n/a Hand Shinobi Passive: n/a Hand Spy Passive: n/a Mindless One Passive: Hand Dragon Passive: Hand Shadow Passive: Hand Soldier Passive: n/a Hand Warrior Passive: n/a

Minimum Cleared: 4
Team-Up: Daredevil

Mini-Boss Wave 1 Hand Ninja Passive: Hand Ninja Passive: Wave 2 Hand Ninja Passive: Hand Ninja Passive: Hand Ninja Passive:

Minimum Cleared: 5
Team-Up: Daredevil
Boss Drops: Chain Blade, Assault Shotgun
Challenge Mode Boss Drop: Custom Revolt

Boss Wave 1 Hand Shinobi Passive: n/a Hand Assassin Passive: n/a Wave 2 Hand Scorpion Passive: n/a Bullseye Passive:

Boss + Mini-Boss Wave 1 Hand Shinobi Passive: n/a Hand Ninja Passive: Hand Assassin Passive: n/a Wave 2 Hand Ninja Passive: Hand Ninja Passive: Hand Ninja Passive: Wave 3 Hand Scorpion Passive: n/a Bullseye Passive: Hand Ninja Passive:

Requirement: Black Cat
Duration: 2 Battles
Unique Drop: Nano-Nurse

Requirement: Any Scrapper
Duration: 2 Battles

Requirement: Any Hero
Duration: 1 Battle

Must finish ALL battles and deploys before the Epic Boss will appear
Team-Up: Daredevil
Epic Boss Drops: Grecian Sai, D.A.R.S. Suppressor
Challenge Mode Epic Boss Drop: Custom Grecian Sai

Epic Boss Hand Shadow Passive: Elektra Passive: Hand Shadow Passive:

Mission 4 - Mean People Edit

Mean People Mastery Stars Score Level 0 12 8,500 14 191,000 16 382,000 18 764,000 20 1,528,000 Agent's

"Organized criminal gangs are going after a secret Iso-8 symposium taking place at the UN Convention Center. It's not the Maggia. Who are these goons, and who's in charge?"
— Mission Preview

Unlock Requirements:
Complete 1 Star Mastery in Chapter 2 - Mission 3

Location: Pier 94
Team-Up: Iron Fist

Low: x1
Medium: x2
High: x2

Enemies Angler Passive: n/a Enforcer Passive: n/a Knuckles Passive: n/a Muscle Passive: n/a Bullets Passive: n/a Framer Passive: n/a Lead Foot Passive: n/a Slicer Passive: n/a

Minimum Cleared: None
Team-Up: Iron Fist

Mini-Boss Jack O'Lantern Passive: Knuckles Passive: n/a

Minimum Cleared: 5
Team-Up: Iron Fist
Boss Drops: Tidal Fist, S.A. "Ambush"
Challenge Mode Boss Drops: Custom Bolt-Action 4 Bore

Boss Wave 1 Mad Dog Passive: n/a Enforcer Passive: n/a Wave 2 The Hood Passive: Lead Foot Passive: n/a

Boss + Mini-Boss Wave 1 Mad Dog Passive: n/a Enforcer Passive: n/a Wave 2 The Hood Passive: Jack O'Lantern Passive: Lead Foot Passive: n/a

Requirement: Any Hero
Duration: 1 Battle

Requirement: Any Bruiser
Duration: 2 Battles

Requirement: Luke Cage
Duration: 1 Battle

Mission 5 - Mutate or Die Edit

Mutate or Die Mastery Stars Score Level 0 13 11,500 15 288,000 17 576,000 19 1,152,000 21 2,304,000 Agent's

"The streets of Yorkville are suddenly full of angry, disoriented...mutants? What's causing this? The X-Men are coming in to assist SHIELD's investigation."
— Mission Preview

Unlock Requirements:
Complete 1 Star Mastery in Chapter 2 - Mission 4

Location: Yorkville
Team-Up: Phoenix

Low: x3
Medium: x3
High: x3

Enemies BL-Alpha Passive: n/a BR-Alpha Passive: n/a IN-Alpha Passive: n/a SC-Beta Passive: n/a BL-Beta Passive: n/a BR-Beta Passive: n/a IN-Beta Passive: n/a TA-Beta Passive: n/a

Team-Up: Phoenix

Mini-Boss 1 SC-Alpha Passive: n/a Mystique Passive: SC-Alpha Passive: n/a

Mini-Boss 2 Juggernaut Passive:

Minimum Cleared: 8
Team-Up: Phoenix
Boss Drops: Batstone 2.357 Minigun, Offensive Accelerator
Challenge Mode Boss Drop: Custom Pyro Technique

Boss Magneto Passive:	Boss + Mini-Boss 1 & 2 Mystique Passive: Magneto Passive: Juggernaut Passive:
Boss + Mini-Boss 1 Mystique Passive: Magneto Passive:	Boss + Mini-Boss 2 Magneto Passive: Juggernaut Passive:

Requirement: Cyclops
Duration: 2 Battle

Requirement: Any Infiltrator
Duration: 3 Battle

Requirement: Any Hero
Duration: 1 Battle

Premium Mission: Ulterior Motive Edit

Ulterior Motive Mastery Stars Score 11,500 241,000 482,000 964,000 1,928,000

"Cybernetic systems are going dangerously rogue in the area around Avengers Mansion. Is this a post-Pulse phenomenon, or something more sinister?"
— Mission Preview

Location: Avengers Mansion
Team-Up: Iron Man
Note: Mission difficulty scales to players' agent level

Medium: x3
High: x2

Enemies Hacked Servoguard Passive: Hacked Servoguard Passive: Hacked Servoguard Passive:

Team-Up: None

Minimum Cleared: 1 Mini-Boss 1 Sentinel Alpha MK IV Passive: Sentinel Alpha MK IV Passive:

Minimum Cleared: 2 Mini-Boss 2 Nimrod Series MK IV Passive: Nimrod Series MK IV Passive:

Minimum Cleared: 7
Team-Up: Iron Man
Boss Drops: EMP Blaster, Uni-Pulse
Challenge Mode Boss Drop: Custom Eagle's Eye

Boss Crimson Dynamo Passive: n/a	Boss + Mini-Boss 1 & 2 Sentinel Alpha MK IV Passive: Crimson Dynamo Passive: n/a Nimrod Series MK IV Passive:
Boss + Mini-Boss 1 Sentinel Alpha MK IV Passive: Crimson Dynamo Passive: n/a	Boss + Mini-Boss 2 Crimson Dynamo Passive: n/a Nimrod Series MK IV Passive:

Requirement: Any Blaster
Duration: 1 Battle

Requirement: Any Hero
Duration: 2 Battle

Requirement: War Machine
Duration: 1 Battle

v · eMissions
Prologue  (Dialogues)
Chapter 1 - The Pulse		Chapter 2 - The Iso Effect
	1. The Hydra's Tail 2. Class is in Session 3. HAIL HYDRA! 4. Designed Only for Killing 5. O Brother, Where Art Thou? Premium Mission: Extra Large		1. In the Family 2. The Sound of Feathers Ruffling 3. Step into the Shadows 4. Mean People 5. Mutate or Die Premium Mission: Ulterior Motive
Dialogues		Dialogues
Chapter 3 - Enter Doom		Chapter 4 - You, Foe
	1. Sacred Ground 2. Brooklyn Bridge is Falling Down 3. RAID-ical Resolution 4. Odd Bedfellows 5. Three Strikes Premium Mission: Cephalocarrier		1. Jailbreak 2. Center Point 3. Hydrophobia 4. Unexpected Guest 5. Command Performance Premium Mission: Tooth and Claw
Dialogues		Dialogues
Chapter 5 - Gods & Monsters		Chapter 6 - Uprising
	1. An Early Frost 2. Taking AIM 3. Chemistry Set 4. Desecration 5. City of Stone Premium Mission: Hydra Assemble!		1. Underworld Masquerade 2. I Predict a Riot 3. Tentacular 4. Mutants Marching 5. Magic Hand Premium Mission: Jailhouse Rock
Dialogues		Dialogues
Chapter 7 - MIA		Chapter 8 - Dark Rites
	1. Anticipation 2. Taking It to the Streets 3. Head Shot 4. Deceiver and Destroyer 5. Chaos Reigns Premium Mission: A Whole New U		1. Enemies Hand in Hand 2. Congressional Action 3. Grand Experiment 4. Quis Custodiet 5. Regeneration Premium Mission: Bring the Thunder
Dialogues		Dialogues
Chapter 9 - The Syndicate		Chapter 10 - Chaos Circle
	1. The Boss is Back 2. Mutatis Mutandis 3. Hand and Fist 4. Weird Science 5. Criminal Minds Premium Mission: Darkness Rising		1. U-Foe Sighting 2. Power Play 3. Stormy Weather 4. Grinning Skull 5. The Syndicate Premium Mission: Der Rote Schadel Lebt Noch
Dialogues		Dialogues
Chapter 11 - Mutant Mayhem		Chapter 12 - Titanomachia
	1. Mutants Take Manhattan 2. HYDRA for Humans! 3. Enter the Circle 4. Underground Resistance 5. Mutation Zone Premium Mission: Breaking the Syndicate		1. Lokasenna 2. Ouroboros 3. Under the Hood 4. Technocrats 5. Feeding Frenzy Premium Mission: Doom's Day
Dialogues		Dialogues